Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064551 | 0.76 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL12770960 | 0.75 | MEN1 (0.68) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL6097668 | 0.74 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL14451978 | 0.74 | MEN1 (1.00) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL13037374 | 0.74 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL11250227 | 0.73 | MEN1 (0.66) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL6094798 | 0.72 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL4234704 | 0.72 | AR (0.77) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL12844535 | 0.72 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL23046929 | 0.71 | MEN1 (0.62) | NPC1RAB9AMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917235-A | Kinase modulation and indications therefor | PLEXXIKON INC | 2014-07-09 | — | — | CN | disclosed |