Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 18/20 | 0.86 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.85 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.85 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.81 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.81 |
| ▸ | LCK | P06239 | 2/20 | 0.81 |
| ▸ | YES1 | P07947 | 2/20 | 0.81 |
| ▸ | RET | P07949 | 2/20 | 0.81 |
| ▸ | KIT | P10721 | 2/20 | 0.81 |
| ▸ | AXL | P30530 | 2/20 | 0.81 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.81 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.81 |
| ▸ | MERTK | Q12866 | 2/20 | 0.81 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.81 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.81 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.81 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.81 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.81 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975780 | 0.95 | EIF2AK3 (0.87) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868503 | 0.93 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL867997 | 0.92 | EIF2AK3 (0.85) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868468 | 0.92 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL869419 | 0.92 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868295 | 0.90 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL29384284 | 0.90 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL30500616 | 0.90 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL29403654 | 0.90 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868254 | 0.90 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | claimed |
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | disclosed |