SCHEMBL28814727

SCHEMBL28814727

Cc1cc(C)c(CNC(=O)c2cc(N(C)C3CCCC3)ccc2C)c(=O)[nH]1

nearest known ligand 0.67

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EZH2 Q15910 20/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27983010 0.83 EZH2 (0.53) EZH2
SCHEMBL13468071 0.82 EZH2 (0.75) EZH2
SCHEMBL13280605 0.82 EZH2 (0.74) EZH2
SCHEMBL15709994 0.81 EZH2 (0.67) EZH2
SCHEMBL13467751 0.80 EZH2 (1.00) EZH2
SCHEMBL13280643 0.80 EZH2 (0.80) EZH2
SCHEMBL13277925 0.80 EZH2 (1.00) EZH2
SCHEMBL13464461 0.80 EZH2 (0.80) EZH2
SCHEMBL13279863 0.80 EZH2 (0.68) EZH2
SCHEMBL13280315 0.80 EZH2 (0.74) EZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104066718-A Substituted benzene compounds EPIZYME INC 2014-09-24 CN disclosed