⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14629863 | 0.74 | — | — | |
| SCHEMBL352063 | 0.59 | — | — | |
| Propane SCHEMBL11599155 | 0.59 | — | — | |
| SCHEMBL98977 | 0.59 | — | — | |
| Ethyl Chloride SCHEMBL11600160 | 0.56 | — | — | |
| Alcohol SCHEMBL2021651 | 0.56 | — | — | |
| SCHEMBL1363067 | 0.56 | — | — | |
| SCHEMBL15228676 | 0.56 | — | — | |
| Ethyl Chloride SCHEMBL1331389 | 0.54 | — | — | |
| Propane SCHEMBL10639899 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024053650-A1 | COMPOUND HAVING INHIBITORY ACTIVITY AGAINST DIACYLGLYCEROL KINASE α AND/OR ζ, AND PHARMACEUTICAL USE THEREOF | 小野薬品工業株式会社 | 2024-03-14 | — | — | WO | disclosed |
| CN-112209884-B | 1-H benzimidazole derivative, preparation method and application thereof | 杭州梯诺医药科技有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-112209884-A | 1-H benzimidazole derivative, preparation method and application thereof | 杭州梯诺医药科技有限公司 | 2021-01-12 | — | — | CN | disclosed |
| US-20170165254-A1 | TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF | GEORGETOWN UNIVERSITY (US) | 2017-06-15 | — | — | US | disclosed |
| EP-3102205-A2 | TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF | Georgetown University (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-3010483-A1 | LYOPHILIZED FORMULATIONS OF BENDAMUSTINE HYDROCHLORIDE | CHEMI S.p.A. (IT) | 2016-04-27 | — | — | EP | disclosed |
| US-9308174-B2 | Lyophilized formulations of bendamustine hydrochloride | CHEMI S.P.A. (IT) | 2016-04-12 | — | — | US | disclosed |
| WO-2015120127-A2 | TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF | GEORGETOWN UNIVERSITY (US) | 2015-08-13 | — | — | WO | disclosed |
| US-20140378518-A1 | LYOPHILIZED FORMULATIONS OF BENDAMUSTINE HYDROCHLORIDE | CHEMI S.P.A. (IT) | 2014-12-25 | — | — | US | disclosed |
| WO-2014202553-A1 | LYOPHILIZED FORMULATIONS OF BENDAMUSTINE HYDROCHLORIDE | CHEMI S.P.A. (IT) | 2014-12-24 | — | — | WO | disclosed |
| US-8183234-B2 | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-05-22 | — | — | US | disclosed |
| US-7834001-B2 | N-(10,10-Dioxo-10,11-dihydro-5-oxa-10-lambda*6*-thia-dibenzo[a.d]cycloheptene-8-carbonyl)-guanidine; tumor necrosis factor inhibitors; sodium-proton exchange inhibitors for treatment of organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2010-11-16 | — | — | US | disclosed |
| US-20100267690-A1 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2010-10-21 | — | — | US | disclosed |
| US-20070299051-A1 | Tricyclic Guanidine Derivatives as Sodium-Proton Exchange Inhibitors | NICHOLAS PIRAMAL INDIA LIMITED. (IN) | 2007-12-27 | — | — | US | disclosed |
| EP-1812420-A1 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS | Nicholas Piramal India Limited (IN) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006051476-A1 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2006-05-18 | — | — | WO | disclosed |