Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.61 |
| ▸ | JAK2 | O60674 | 11/20 | 0.61 |
| ▸ | JAK1 | P23458 | 6/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516803 | 0.85 | TYK2 (0.66) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL4063941 | 0.77 | S1PR1 (0.51) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3515230 | 0.76 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3514136 | 0.74 | TYK2 (0.72) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3514963 | 0.74 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3513787 | 0.74 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3515423 | 0.74 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL1706029 | 0.73 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL1707688 | 0.73 | TYK2 (0.70) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3513725 | 0.73 | TYK2 (0.98) | TYK2JAK2JAK1CDK9JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459187-B | Janus Kinase Inhibiting Compounds and Methods | HOFFMANN LA ROCHE | 2015-06-17 | — | — | CN | claimed |