Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28819963 | 1.00 | IDO1 (0.50) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| Bromide SCHEMBL3945418 | 0.89 | IDO1 (0.50) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| Bromide SCHEMBL29012388 | 0.89 | IDO1 (0.50) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL8229408 | 0.87 | IDO1 (0.51) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL11412611 | 0.87 | IDO1 (0.51) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL27769197 | 0.86 | IDO1 (0.50) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL10500167 | 0.84 | IDO1 (0.54) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL12214491 | 0.83 | HTR2A (0.53) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL7275342 | 0.83 | HTR2A (0.53) | IDO1RAB9AHTR2AAKR1C3DPP8 | |
| SCHEMBL6400055 | 0.83 | IDO1 (0.53) | IDO1RAB9AHTR2AAKR1C3DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114917361-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |