Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 9/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887646 | 0.83 | CYP3A4 (0.77) | CYP3A4CYP2C19CSF1RKITCYP2C9 | |
| SCHEMBL28018895 | 0.82 | CYP2C9 (0.55) | CYP3A4CYP2C19PRKCQCSF1RKIT | |
| SCHEMBL28018897 | 0.80 | CYP3A4 (0.58) | CYP3A4CYP2C19GPR84CSF1RKIT | |
| SCHEMBL28108746 | 0.79 | CYP3A4 (0.54) | CYP3A4CYP2C19GPR84CSF1RKIT | |
| SCHEMBL28108734 | 0.78 | CYP3A4 (0.56) | CYP3A4CYP2C19CSF1RKITCYP2C9 | |
| SCHEMBL28018398 | 0.75 | CYP2C9 (0.55) | CYP3A4CYP2C19CSF1RCYP2C9 | |
| SCHEMBL1267406 | 0.75 | CYP3A4 (0.60) | CYP3A4CYP2C19CDC7MAP4K4PIM1 | |
| SCHEMBL1890594 | 0.73 | CYP3A4 (0.60) | CYP3A4CYP2C19CDC7MAP4K4PIM1 | |
| SCHEMBL1883948 | 0.72 | CYP3A4 (0.77) | CYP3A4CYP2C19CDC7MAP4K4PIM1 | |
| SCHEMBL1881856 | 0.71 | CYP3A4 (0.66) | CYP3A4CYP2C19CSF1RKITCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104703623-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2015-06-10 | — | — | CN | disclosed |