Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29880182 | 1.00 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29429853 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21106333 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19438916 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19451340 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL23702572 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30834691 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21815163 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19451344 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19475659 | 0.89 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114933589-B | Compound for inducing FGFR degradation based on CRBN ligand and preparation method and application thereof | 杭州医学院 | 2024-03-26 | — | — | CN | disclosed |
| CN-116178339-A | HDAC degradation agent with oxygenated alkane as connecting chain, and preparation method and application thereof | 杭州医学院 | 2023-05-30 | — | — | CN | disclosed |
| CN-114933589-A | CRBN ligand-based FGFR degradation inducing compound and preparation method and application thereof | 杭州医学院 | 2022-08-23 | — | — | CN | disclosed |