SCHEMBL28823757

SCHEMBL28823757

CC(=O)N1CCC(Oc2ccc3c(c2)N(C)CCN(CC(O)CN2CCc4ccccc4C2)C3)CC1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.79
WDR77 Q9BQA1 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28823755 1.00 PRMT5 (0.79) PRMT5WDR77
SCHEMBL28823684 0.95 PRMT5 (0.79) PRMT5WDR77
SCHEMBL28823719 0.95 PRMT5 (0.79) PRMT5WDR77
SCHEMBL28823717 0.95 PRMT5 (0.79) PRMT5WDR77
SCHEMBL28823681 0.95 PRMT5 (0.79) PRMT5WDR77
SCHEMBL28823754 0.92 PRMT5 (0.78) PRMT5WDR77
SCHEMBL28823732 0.91 PRMT5 (0.75) PRMT5WDR77
SCHEMBL28823730 0.91 PRMT5 (0.75) PRMT5WDR77
SCHEMBL23160571 0.89 PRMT5 (1.00) PRMT5WDR77
SCHEMBL23160570 0.89 PRMT5 (1.00) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114929691-A Bicyclic compounds and uses thereof 爱思开生物制药株式会社 2022-08-19 CN disclosed