Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 8/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975573 | 0.84 | GSK3B (0.46) | GSK3BRAB9APIK3CAPIK3CGNPC1 | |
| SCHEMBL2880302 | 0.84 | GSK3B (0.46) | GSK3BRAB9APIK3CAPIK3CGNPC1 | |
| SCHEMBL212025 | 0.71 | MYC (0.77) | GSK3BRAB9APIM1PIM2PIM3 | |
| SCHEMBL5672232 | 0.71 | MYC (0.77) | GSK3BRAB9APIM1PIM2PIM3 | |
| SCHEMBL212026 | 0.71 | MYC (0.77) | GSK3BRAB9APIM1PIM2PIM3 | |
| SCHEMBL2877631 | 0.70 | PIK3CG (0.60) | GSK3BPIK3CG | |
| SCHEMBL2882197 | 0.69 | GSK3B (0.83) | GSK3BRAB9APIK3CAPIK3CGNPC1 | |
| SCHEMBL1249098 | 0.69 | GSK3B (0.83) | GSK3BRAB9APIK3CAPIK3CGNPC1 | |
| SCHEMBL2882080 | 0.69 | GSK3B (1.00) | GSK3BRAB9APIK3CAPIK3CGNPC1 | |
| SCHEMBL29774248 | 0.69 | GSK3B (0.69) | GSK3BRAB9APIK3CAPIK3CGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | BRCA1, ZAP70, F13B | GSK3B 3188/4885RAB9A 1504/4885PIK3CA 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.