Norethynodrel

SCHEMBL28828334

C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C.C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C.CC(=O)O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Norethynodrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PGR known ✓	P06401	6/20	0.72

▸	CYP3A4	P08684	7/20	0.72

▸	LMNA	P02545	6/20	0.72

▸	CYP2C19	P33261	6/20	0.72

▸	ABCB11	O95342	5/20	0.72

▸	SLC6A4	P31645	5/20	0.72

▸	ESR1	P03372	4/20	0.72

▸	NR3C1	P04150	4/20	0.72

▸	TSHR	P16473	2/20	0.72

▸	SHBG	P04278	2/20	0.72

▸	HIF1A	Q16665	2/20	0.72

▸	ALDH1A1	P00352	2/20	0.72

▸	ADRA2A	P08913	1/20	0.72

▸	AR	P10275	3/20	0.70

▸	MAPT	P10636	3/20	0.70

▸	ADORA3	P0DMS8	3/20	0.70

▸	ALOX15	P16050	2/20	0.70

▸	CHRM1	P11229	2/20	0.70

▸	TBXA2R	P21731	2/20	0.70

▸	ADRA1A	P35348	2/20	0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Norethindrone Acetate SCHEMBL28828333	0.91	CYP3A4 (0.72)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL37531	0.89	CYP3A4 (0.92)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL11291575	0.86	CYP3A4 (0.94)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL14074493	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL6834811	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL24476231	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL19510084	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL7768886	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL14577661	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11
Norethindrone SCHEMBL23390	0.85	CYP3A4 (1.00)	CYP3A4LMNACYP2C19PGRABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-102946865-B	Comprise the pharmaceutical emulsion composition of the low oil of progestogen	博赏医药卢森堡责任有限公司	2016-06-22	—	—	CN	disclosed