Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831825 | 0.79 | PDE2A (0.46) | ADORA3KMT2AHPGDHTT | |
| SCHEMBL21943145 | 0.78 | CYP1A2 (0.40) | ADORA3ADORA2BKMT2APNPMAPK1 | |
| SCHEMBL2836366 | 0.77 | PDE2A (0.42) | ADORA3KMT2AHPGDHTT | |
| SCHEMBL1959212 | 0.77 | PDE2A (0.42) | ADORA3MAPTKMT2APNPPOLB | |
| SCHEMBL1961857 | 0.76 | HPGD (0.42) | KMT2APOLBLMNAMAPK1ALDH1A1 | |
| SCHEMBL1960594 | 0.76 | PDE2A (0.43) | ADORA3MAPTKMT2APOLBHPGD | |
| SCHEMBL2833418 | 0.76 | KMT2A (0.40) | KMT2APOLBLMNAALDH1A1HPGD | |
| SCHEMBL1962754 | 0.75 | PDE2A (0.42) | ADORA3KMT2AHPGDHTT | |
| SCHEMBL7360012 | 0.74 | HPGD (0.47) | ADORA3MAPTKMT2APOLBHPGD | |
| SCHEMBL1960096 | 0.74 | PDE2A (0.42) | ADORA3MAPTKMT2APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666872-B2 | Use for PDE5 inhibitors | NYCOMED GMBH (DE) | 2010-02-23 | — | — | US | disclosed |
| US-20070185114-A1 | Novel use for pde5 inhibitors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |