Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | GAA | P10253 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220303 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL31019418 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL7218658 | 0.75 | NR4A2 (0.59) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL701263 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL4779330 | 0.72 | GAA (0.59) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL1548445 | 0.72 | KDM4E (0.52) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL28325027 | 0.71 | KDM4E (0.62) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL5327857 | 0.70 | GAA (0.56) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL8794998 | 0.70 | GAA (0.58) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL28025010 | 0.70 | GAA (0.53) | KDM4EALDH1A1GAAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028644-A | SOS1 inhibitor heterocyclic compounds | 首药控股(北京)股份有限公司 | 2022-09-09 | — | — | CN | disclosed |