Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.65 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321947 | 0.87 | NOTUM (0.49) | NOTUMMYCARALDH1A1KDM4E | |
| SCHEMBL13041773 | 0.83 | WDR91 (0.46) | NOTUMMYCPOLBARALDH1A1 | |
| SCHEMBL2022337 | 0.82 | HDAC1 (0.53) | NOTUMMYCAR | |
| SCHEMBL30955281 | 0.82 | HDAC1 (0.53) | NOTUMMYCAR | |
| SCHEMBL13153052 | 0.82 | NOTUM (0.65) | NOTUMCYP2D6CYP2C9POLB | |
| SCHEMBL28494012 | 0.82 | MYC (0.46) | NOTUMMYCPOLBALDH1A1KDM4E | |
| SCHEMBL14886462 | 0.79 | MYC (0.41) | NOTUMMYCPOLBALDH1A1KDM4E | |
| SCHEMBL3895361 | 0.79 | NOTUM (1.00) | NOTUMALDH1A1 | |
| SCHEMBL30730960 | 0.79 | NOTUM (1.00) | NOTUMALDH1A1 | |
| SCHEMBL15555766 | 0.79 | CNR2 (0.69) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028644-A | SOS1 inhibitor heterocyclic compounds | 首药控股(北京)股份有限公司 | 2022-09-09 | — | — | CN | disclosed |