Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.54 |
| ▸ | DRD3 | P35462 | 9/20 | 0.50 |
| ▸ | DRD2 | P14416 | 7/20 | 0.50 |
| ▸ | DRD4 | P21917 | 6/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28836214 | 0.86 | DRD3 (0.51) | HRH3DRD3DRD2DRD4DRD1 | |
| SCHEMBL28836355 | 0.83 | HRH3 (0.71) | HRH3P2RX3KCNH2 | |
| SCHEMBL28836369 | 0.83 | HRH3 (0.57) | HRH3DRD3DRD2DRD4P2RX3 | |
| SCHEMBL29782994 | 0.83 | HRH3 (0.57) | HRH3DRD3DRD2DRD4P2RX3 | |
| SCHEMBL29783057 | 0.82 | HRH3 (0.55) | HRH3DRD3DRD2DRD4P2RX3 | |
| SCHEMBL28836348 | 0.82 | HRH3 (0.55) | HRH3DRD3DRD2DRD4P2RX3 | |
| SCHEMBL28836225 | 0.80 | HIF1A (0.43) | HRH3P2RX3 | |
| SCHEMBL29783146 | 0.80 | HIF1A (0.43) | HRH3P2RX3 | |
| SCHEMBL29783102 | 0.80 | HRH3 (0.54) | HRH3DRD3DRD2DRD4DRD1 | |
| SCHEMBL28836178 | 0.79 | HRH3 (0.65) | HRH3DRD3DRD2DRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989085-B | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-114989085-A | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2022-09-02 | — | — | CN | disclosed |