SCHEMBL2883678

SCHEMBL2883678

CC1(C)Oc2cc(NS(=O)(=O)C(F)(F)F)ccc2[C@H](OC(=O)NCCc2ccccc2)[C@H]1O

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 12/20 0.46
LMNA P02545 2/20 0.35
GAA P10253 1/20 0.35
HTT P42858 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PTPN1 P18031 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2889346 0.89 KCNA5 (0.44) KCNA5
SCHEMBL2891657 0.89 KCNA5 (0.44) KCNA5
SCHEMBL2889515 0.85 KCNA5 (0.43) KCNA5LMNAGAAHTT
SCHEMBL2887356 0.85 KCNA5 (0.55) KCNA5GAA
SCHEMBL2891262 0.83 KCNA5 (0.43) KCNA5LMNAGAAHTT
SCHEMBL2883892 0.83 KCNA5 (0.46) KCNA5
SCHEMBL2883788 0.81 KCNA5 (0.43) KCNA5GAAHTT
Maleic Acid SCHEMBL2891985 0.80 KCNA5 (0.44) KCNA5
Fumaric Acid SCHEMBL2891986 0.80 KCNA5 (0.44) KCNA5
SCHEMBL2883681 0.80 KCNA5 (0.42) KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1718629-B1 Benzopyran compounds useful for the treatment of arrhytmia NISSAN CHEMICAL IND LTD (JP) 2012-12-26 EP disclosed
US-7781483-B2 Benzopyran compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-08-24 US disclosed
US-20070299130-A1 Benzopyran Compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070299130-A1 Benzopyran Compound NR0B1, CYP2B6, RYR2 KCNA5 69/4885LMNA 2284/4885GAA 4316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.