Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.60 |
| ▸ | DYRK2 | Q92630 | 11/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 10/20 | 0.60 |
| ▸ | PIM1 | P11309 | 9/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 9/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.60 |
| ▸ | CSNK2A3 | Q8NEV1 | 9/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | CLK3 | P49761 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899865 | 1.00 | DYRK1A (0.60) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL23510557 | 1.00 | DYRK1A (0.60) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL28842915 | 0.84 | DYRK1A (0.45) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL24904253 | 0.84 | DYRK1A (0.45) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL29899881 | 0.84 | DYRK1A (0.45) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL23510632 | 0.78 | CLK1 (0.62) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL29899840 | 0.78 | CLK1 (0.62) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL28842979 | 0.78 | CLK1 (0.62) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL26095844 | 0.77 | DYRK1A (0.37) | DYRK1ADYRK2DYRK1BDYRK3PIM1 | |
| SCHEMBL26096583 | 0.77 | DYRK1A (0.37) | DYRK1ADYRK2DYRK1BDYRK3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929690-B | Novel heterocyclic derivatives having cardiomyocyte proliferative activity for the treatment of heart disease | 同济大学 | 2023-05-05 | — | — | CN | disclosed |
| CN-114929690-A | Novel heterocyclic derivatives with cardiomyocyte proliferative activity for the treatment of cardiac diseases | 同济大学 | 2022-08-19 | — | — | CN | disclosed |