Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 8/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28016419 | 0.93 | — | — | |
| Acetic Acid SCHEMBL28304587 | 0.87 | — | — | |
| SCHEMBL962286 | 0.83 | — | — | |
| Acetone SCHEMBL28320419 | 0.83 | — | — | |
| Hydrogen Peroxide SCHEMBL28182850 | 0.82 | — | — | |
| Bicarbonate SCHEMBL29018922 | 0.79 | TSHR (0.63) | TSHRTDP1CES2CES1ALDH1A1 | |
| SCHEMBL27786864 | 0.79 | — | — | |
| Acetone SCHEMBL10338997 | 0.79 | — | — | |
| Butane SCHEMBL9235538 | 0.78 | FFAR3 (0.50) | FFAR3HDAC1HDAC2HDAC3HDAC8 | |
| Bicarbonate SCHEMBL9303939 | 0.78 | FFAR3 (0.50) | FFAR3HDAC1HDAC2HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108721187-A | A kind of antipruritic protective cream of children | 广州市华晟健康产业有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-108653156-A | Anti-allergy temperature-sensing and shower gel | 夏新河 | 2018-10-16 | — | — | CN | disclosed |
| CN-108498464-A | A kind of enteral administration bioadhesive microspheres preparation | 广东伊茗药业有限公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-108338935-A | A kind of beauty mask containing polypeptide | 珍尔姿（广州）化妆品有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108186744-A | It is a kind of that there is antipruritic antibacterial topical composition | 啵噜噜（广州）婴儿用品科技有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-108042468-A | A kind of cosmetic composition with balanced whitening effect | 珍尔姿（广州）化妆品有限公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-107929137-A | A kind of cosmetic composition of anti-aging | 珍尔姿（广州）化妆品有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107929369-A | A kind of medicament for treating child skin eczema | 无比滴（广东）药业有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107822937-A | A kind of cosmetic composition for eyelashes | 珍尔姿（广州）化妆品有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107412110-A | A kind of more effect spray cleaning filters | 无比滴（广东）药业有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107296777-A | It is a kind of that there is makeup removing, refrigerant and maintenance cutin face cleaning gel | 珍尔姿（广州）化妆品有限公司 | 2017-10-27 | — | — | CN | disclosed |
| CN-106619987-A | Externally-applied agent for prevention and treatment of pruritus and eczema at female sensitive position | 广东伊茗药业有限公司 | 2017-05-10 | — | — | CN | disclosed |