Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28364963 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL1679613 | 0.95 | — | — | |
| Bicarbonate SCHEMBL1315939 | 0.94 | — | — | |
| Bicarbonate SCHEMBL4790627 | 0.89 | — | — | |
| Bicarbonate SCHEMBL1498980 | 0.89 | CA4 (0.42) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL8723912 | 0.89 | CA4 (0.55) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL176206 | 0.89 | — | — | |
| Bicarbonate SCHEMBL21518592 | 0.89 | — | — | |
| Bicarbonate SCHEMBL175847 | 0.89 | CA4 (0.42) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL176182 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115058059-B | Calcium-zinc heat stabilizer for PVC, preparation method and application | 江苏大学 | 2024-08-30 | — | — | CN | disclosed |
| CN-115058059-A | Calcium-zinc heat stabilizer for PVC (polyvinyl chloride), and preparation method and application thereof | 江苏大学 | 2022-09-16 | — | — | CN | disclosed |