Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048179 | 0.80 | MAPK1 (0.43) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31463327 | 0.80 | MAPK1 (0.67) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL164488 | 0.80 | MAPK1 (0.67) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31463324 | 0.80 | MAPK1 (0.67) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL1585177 | 0.78 | MAPK1 (0.65) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL26672328 | 0.78 | KDM4E (0.46) | MAPK1KDM4EL3MBTL1P4HTMALDH1A1 | |
| SCHEMBL28020808 | 0.78 | KDM4E (0.60) | MAPK1KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL6527953 | 0.77 | GRIN2B (0.40) | GRIN2BKDM4EP4HTMP4HA1MIF | |
| SCHEMBL229176 | 0.76 | CA12 (0.55) | MAPK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL15721346 | 0.74 | P4HTM (0.42) | MAPK1KDM4EL3MBTL1P4HTMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795147-A | Cyclopropyl fused thiazine-2-amine compounds as beta-secretase inhibitors and methods of use | 美国安进公司 | 2017-05-31 | — | — | CN | disclosed |