SCHEMBL2884826

SCHEMBL2884826

CC(C)(C)c1ccccc1OC(=O)Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.58
ATM Q13315 1/20 0.58
BCHE P06276 1/20 0.51
ALDH1A1 P00352 5/20 0.50
KDM4E B2RXH2 4/20 0.50
GAA P10253 3/20 0.50
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
NPSR1 Q6W5P4 1/20 0.43
NAMPT P43490 1/20 0.43
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
RBP4 P02753 3/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ELANE P08246 1/20 0.41
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254573 0.89 TDP1 (0.46) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL30134334 0.84 TDP1 (0.62) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL27853484 0.84 TDP1 (0.72) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL47807 0.84 TDP1 (0.62) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL10794557 0.82 TDP1 (0.40) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL1789658 0.82 TDP1 (0.60) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL6403938 0.82 TDP1 (0.60) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL47808 0.82 TDP1 (0.65) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL31304747 0.82 TDP1 (0.65) TDP1ATMBCHEALDH1A1KDM4E
SCHEMBL7107069 0.82 TDP1 (0.45) TDP1ATMBCHEALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2049583-B1 POLYSILOXANE COPOLYMERS,THERMOPLASTIC COMPOSITION, AND ARTICLES FORMED THEREFROM SABIC GLOBAL TECHNOLOGIES BV (NL) 2019-11-06 EP disclosed
US-7790292-B2 Polysiloxane copolymers, thermoplastic composition, and articles formed therefrom SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-09-07 US disclosed
EP-2049583-A1 POLYSILOXANE COPOLYMERS,THERMOPLASTIC COMPOSITION, AND ARTICLES FORMED THEREFROM Sabic Innovative Plastics IP B.V. (NL) 2009-04-22 EP disclosed
WO-2008021673-A1 POLYSILOXANE COPOLYMERS,THERMOPLASTIC COMPOSITION, AND ARTICLES FORMED THEREFROM SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-02-21 WO disclosed
US-20070129492-A1 POLYSILOXANE COPOLYMERS, THERMOPLASTIC COMPOSITION, AND ARTICLES FORMED THEREFROM GENERAL ELECTRIC COMPANY (US) 2007-06-07 US disclosed
EP-0262695-B1 METHOD OF PREPARING AN AROMATIC POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 1992-04-15 EP disclosed
US-4864011-A MOLECULAR WEIGHT CONTROL GENERAL ELECTRIC COMPANY (US) 1989-09-05 US disclosed
EP-0262695-A1 Method of preparing an aromatic polycarbonate GENERAL ELECTRIC COMPANY (US) 1988-04-06 EP disclosed
US-4403056-A POLYVINYL CHLORIDE PLASTICIZER STAUFFER CHEMICAL COMPANY (US) 1983-09-06 US disclosed