Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 13/20 | 0.77 |
| ▸ | CDK9 | P50750 | 6/20 | 0.71 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.71 |
| ▸ | CDK2 | P24941 | 5/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848507 | 0.87 | USP8 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667342 | 0.86 | CCNT1 (0.85) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848525 | 0.84 | USP8 (0.60) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667343 | 0.84 | CCNT1 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848511 | 0.80 | USP8 (0.70) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667334 | 0.78 | CCNT1 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667340 | 0.76 | USP8 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667264 | 0.75 | USP8 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667341 | 0.75 | USP8 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848519 | 0.75 | USP8 (0.55) | USP8CDK9CCNT1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-B | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |