SCHEMBL28849012

SCHEMBL28849012

O=C(O)c1c(O)c2ccccc2n(CC2CN(c3ccccc3)C(=O)O2)c1=O

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 12/20 0.47
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 3/20 0.42
F10 P00742 1/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28849009 1.00 GRM2 (0.47) GRM2MEN1KMT2AKDM4EF10
SCHEMBL28849034 0.87 EGLN1 (0.58) MEN1KMT2AKDM4ESMN1; SMN2L3MBTL1
SCHEMBL29950091 0.87 KDM4E (0.62) GRM2MEN1KMT2AKDM4EALDH1A1
SCHEMBL29950257 0.87 KDM4E (0.62) GRM2MEN1KMT2AKDM4EALDH1A1
SCHEMBL28849092 0.87 EGLN1 (0.58) MEN1KMT2AKDM4ESMN1; SMN2L3MBTL1
SCHEMBL28849142 0.87 KDM4E (0.62) GRM2MEN1KMT2AKDM4EALDH1A1
SCHEMBL29950086 0.87 EGLN1 (0.58) MEN1KMT2AKDM4ESMN1; SMN2L3MBTL1
SCHEMBL11372077 0.77 GSK3B (0.60) MEN1KMT2AKDM4EALDH1A1HTT
SCHEMBL7435419 0.72 KDM4E (0.72) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL4638737 0.69 GRM2 (0.69) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108069952-B Quinolinone compound and application thereof in medicines 广东东阳光药业有限公司 2022-09-27 CN disclosed