Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21413873 | 0.78 | JAK1 (0.45) | ACACBJAK1JAK2TYK2JAK3 | |
| SCHEMBL19738337 | 0.76 | SYK (0.39) | LCKSYK | |
| SCHEMBL29838697 | 0.75 | JAK3 (0.41) | ACACBJAK1JAK2TYK2JAK3 | |
| SCHEMBL28937403 | 0.74 | CA12 (0.38) | LCKCA12CA1CA9PSMB8 | |
| SCHEMBL27392791 | 0.73 | JAK2 (0.44) | JAK1JAK2SYK | |
| SCHEMBL13759613 | 0.73 | ATR (0.42) | JAK1JAK2TYK2JAK3RAB9A | |
| SCHEMBL23458587 | 0.72 | JAK3 (0.39) | ACACBJAK1JAK2TYK2JAK3 | |
| SCHEMBL2768352 | 0.71 | CA12 (0.39) | RAB9ANPC1MEN1KMT2ALCK | |
| SCHEMBL21961534 | 0.70 | GSK3B (0.40) | JAK1RAB9ANPC1MEN1GAA | |
| SCHEMBL29510819 | 0.70 | GSK3B (0.40) | JAK1RAB9ANPC1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135651-A | Substituted nucleoside analogs as PRMT5 inhibitors | 鲁皮恩有限公司 | 2022-09-30 | — | — | CN | disclosed |