Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Furan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furan SCHEMBL27410646 | 0.97 | HPRT1 (0.44) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Phenanthrene SCHEMBL27776376 | 0.97 | HPRT1 (0.44) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL27257225 | 0.97 | HPRT1 (0.44) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL27350894 | 0.97 | HPRT1 (0.44) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL28784294 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL27571744 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL27539764 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL27944173 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Naphthalene SCHEMBL28211452 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 | |
| Furan SCHEMBL28165428 | 0.95 | HPRT1 (0.42) | HPRT1KIF11ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105618143-B | A kind of seven yuan of azepine magnesium metallic catalysts and its preparation method and application | 山西大学 | 2017-11-03 | — | — | CN | disclosed |