Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA3 | P07451 | 3/20 | 0.36 |
| ▸ | CA6 | P23280 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17577773 | 0.78 | FLT3 (0.52) | HDAC6IDO1CA12CA2CA9 | |
| SCHEMBL29988390 | 0.77 | IDO1 (0.53) | HDAC6IDO1F2F10CA12 | |
| SCHEMBL31095794 | 0.77 | IDO1 (0.55) | HDAC6IDO1F2F10CA12 | |
| SCHEMBL9430490 | 0.77 | MAOB (0.49) | HDAC6IDO1CA12CA2CA6 | |
| SCHEMBL4521699 | 0.77 | HDAC6 (0.42) | HDAC6IDO1F2F10LOXL2 | |
| SCHEMBL4689215 | 0.77 | FLT3 (0.55) | HDAC6IDO1F2F10LOXL2 | |
| SCHEMBL120819 | 0.77 | IDO1 (0.55) | HDAC6IDO1F2F10CA12 | |
| SCHEMBL120404 | 0.77 | IDO1 (0.53) | HDAC6IDO1F2F10LOXL2 | |
| SCHEMBL10422458 | 0.77 | IDO1 (0.53) | HDAC6IDO1F2F10CA12 | |
| SCHEMBL6870685 | 0.77 | HDAC6 (0.40) | HDAC6IDO1F2F10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107383024-B | The class compound of fused tricyclic containing imidazoles and its application | 广州必贝特医药技术有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107383024-A | The class compound of fused tricyclic containing imidazoles and its application | 广州必贝特医药技术有限公司 | 2017-11-24 | — | — | CN | disclosed |