Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.54 |
| ▸ | JAK3 | P52333 | 8/20 | 0.54 |
| ▸ | LCK | P06239 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.37 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 6/20 | 0.37 |
| ▸ | STAT3 | P40763 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856922 | 1.00 | BTK (0.54) | BTKJAK3LCKEGFRAURKB | |
| SCHEMBL28856953 | 0.87 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL28856948 | 0.87 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL22346834 | 0.84 | BTK (0.63) | BTKJAK3LCKEGFR | |
| SCHEMBL22346831 | 0.84 | BTK (0.63) | BTKJAK3LCKEGFR | |
| SCHEMBL22359022 | 0.81 | JAK3 (0.66) | BTKJAK3LCKEGFRAURKB | |
| SCHEMBL29556712 | 0.81 | JAK3 (0.66) | BTKJAK3LCKEGFRAURKB | |
| SCHEMBL28856906 | 0.81 | JAK3 (0.47) | BTKJAK3LCKEGFR | |
| SCHEMBL28856908 | 0.81 | JAK3 (0.47) | BTKJAK3LCKEGFR | |
| SCHEMBL28856965 | 0.79 | JAK3 (0.54) | BTKJAK3LCKEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003304-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 纽力克斯治疗公司 | 2022-09-02 | — | — | CN | disclosed |