SCHEMBL28857038

SCHEMBL28857038

Cn1cc(-c2ccnc(Nc3ncccn3)n2)c2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 1/20 0.64
MKNK2 Q9HBH9 1/20 0.64
EGFR P00533 13/20 0.63
FLT3 P36888 2/20 0.59
HDAC1 Q13547 4/20 0.58
GSK3B P49841 2/20 0.56
HDAC3 O15379 2/20 0.52
HDAC4 P56524 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52
HDAC5 Q9UQL6 2/20 0.52
CCNE1 P24864 1/20 0.51
CDK2 P24941 1/20 0.51
CCNB2 O95067 1/20 0.50
CDK1 P06493 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28857003 0.90 MKNK1 (0.60) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL28856980 0.85 EGFR (0.62) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129576 0.85 EGFR (0.68) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129607 0.85 MKNK1 (0.58) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL2547336 0.85 EGFR (0.71) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129517 0.85 EGFR (0.68) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129715 0.84 MKNK1 (0.57) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL28856985 0.84 MKNK1 (0.57) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129265 0.84 MKNK1 (0.56) MKNK1MKNK2EGFRFLT3HDAC1
SCHEMBL30129279 0.83 MKNK2 (0.73) MKNK1MKNK2EGFRFLT3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113563310-B 4- (1-methylindol-3-yl) pyrimidine derivative and application thereof 浙江工业大学 2022-10-11 CN disclosed