Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16687886 | 0.76 | NOTUM (0.41) | HTR7HTR2BHTR1AHTR2CNOTUM | |
| SCHEMBL21662887 | 0.74 | NOTUM (0.33) | NOTUMHPGDNPC1RAB9ALMNA | |
| SCHEMBL20088333 | 0.74 | NOTUM (0.35) | SIGMAR1HTR2BHTR2CADRA2CNOTUM | |
| SCHEMBL23561017 | 0.74 | GRM5 (0.54) | SIGMAR1TMEM97NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7262697 | 0.74 | NOTUM (0.40) | HTR7HTR2BSLC6A2HTR1AHTR2C | |
| SCHEMBL13647676 | 0.71 | NOTUM (0.38) | SLC6A2NOTUMHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2625757 | 0.71 | NOTUM (0.38) | SLC6A2HTR1AADRA2AADRA1ASLC6A3 | |
| SCHEMBL8013849 | 0.71 | TMEM97 (0.40) | SIGMAR1TMEM97HTR7HTR2BSLC6A2 | |
| SCHEMBL3304748 | 0.70 | NOTUM (0.50) | SIGMAR1TMEM97HTR7HTR2BSLC6A2 | |
| SCHEMBL11430704 | 0.70 | NPC1 (0.53) | SIGMAR1SLC6A2ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189461-B | The dibasic 1- acyl groups -4- amino -1,2,3,4- tetrahydroquinoline derivatives of 2,3- and their purposes as bromine domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-05-15 | — | — | CN | disclosed |