Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 5/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171846 | 0.86 | EGFR (0.50) | EGFRJAK1JAK3JAK2LRRK2 | |
| SCHEMBL18181558 | 0.85 | JAK1 (0.53) | EGFRJAK1JAK3JAK2LRRK2 | |
| SCHEMBL18171849 | 0.82 | JAK1 (0.50) | EGFRJAK1JAK3JAK2LRRK2 | |
| SCHEMBL18181611 | 0.80 | JAK1 (0.50) | EGFRJAK1JAK3JAK2LRRK2 | |
| SCHEMBL20073216 | 0.78 | JAK1 (0.49) | EGFRJAK1JAK3JAK2LRRK2 | |
| SCHEMBL15358443 | 0.76 | SYK (0.60) | EGFRJAK3JAK2SYKIGF1R | |
| SCHEMBL28221625 | 0.76 | PLK4 (0.56) | JAK1JAK3JAK2IGF1R | |
| SCHEMBL18181563 | 0.75 | MAPT (0.51) | EGFRCYP1A2CSF1RDAPK1KCNH2 | |
| SCHEMBL15349506 | 0.75 | SYK (0.59) | EGFRJAK3JAK2SYKIGF1R | |
| SCHEMBL468661 | 0.74 | CYP1A2 (0.58) | DGAT1CYP1A2MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137593-A | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | 上海交通大学医学院附属瑞金医院 | 2018-06-08 | — | — | CN | disclosed |