Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12688 | 0.98 | TEK (0.58) | TEKPFKFB3DYRK1ACLK1CLK2 | |
| Ammonia Solution, Strong SCHEMBL18398436 | 0.81 | FLT3 (0.56) | DYRK1ACLK1CLK2HIPK1DYRK2 | |
| SCHEMBL19259764 | 0.80 | DYRK1A (0.48) | DYRK1ACLK1CLK2HIPK1DYRK2 | |
| SCHEMBL17809818 | 0.79 | ERN1 (0.45) | TEKDYRK1AAXLMETAP2LRRK2 | |
| Ammonia Solution, Strong SCHEMBL18398465 | 0.79 | KDR (0.55) | PFKFB3DYRK1AAXLMETAP2 | |
| SCHEMBL24289812 | 0.79 | KMT2A (0.44) | TEKPFKFB3METAP2 | |
| SCHEMBL19662770 | 0.79 | DYRK1A (0.47) | DYRK1ACLK1CLK2HIPK1DYRK2 | |
| SCHEMBL22445210 | 0.79 | FYN (0.60) | PFKFB3DYRK1ACLK1CLK2HIPK1 | |
| SCHEMBL30269944 | 0.79 | AURKB (0.54) | DYRK1ACLK1CLK2HIPK1DYRK2 | |
| SCHEMBL8376983 | 0.79 | KCNH2 (0.58) | DYRK1ACLK1CLK2HIPK1DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |