Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.73 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.73 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.73 |
| ▸ | HRH2 | P25021 | 2/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.73 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.73 |
| ▸ | HTR1B | P28222 | 1/20 | 0.73 |
| ▸ | HTR2A | P28223 | 1/20 | 0.73 |
| ▸ | HTR7 | P34969 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.73 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.73 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.53 |
| ▸ | SCN4A | P35499 | 3/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL4795641 | 1.00 | DRD3 (0.73) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4797279 | 0.89 | DRD3 (0.92) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL29206579 | 0.88 | DRD3 (0.85) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL28865276 | 0.88 | DRD3 (0.85) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL28364741 | 0.88 | DRD3 (0.85) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL6150982 | 0.86 | DRD3 (0.61) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL1256055 | 0.86 | DRD3 (0.81) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL28400320 | 0.86 | DRD3 (0.81) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL2460236 | 0.85 | DRD3 (0.80) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Dexpramipexole SCHEMBL20626742 | 0.85 | DRD3 (0.80) | DRD3DRD2HRH2ADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215818-B | Pramipexole triphenyl acetate and drug sustained release preparation thereof | 山东京卫制药有限公司 | 2023-03-17 | — | — | CN | claimed |
| CN-115215818-A | Pramipexole triphenyl acetate and drug sustained release preparation thereof | 山东京卫制药有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-115215818-B | Pramipexole triphenyl acetate and drug sustained release preparation thereof | 山东京卫制药有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-115215818-A | Pramipexole triphenyl acetate and drug sustained release preparation thereof | 山东京卫制药有限公司 | 2022-10-21 | — | — | CN | disclosed |