Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | BCR | P11274 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968183 | 0.84 | NR1H4 (0.53) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL29967504 | 0.84 | NR1H4 (0.44) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL28957360 | 0.84 | NR1H4 (0.53) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL28871209 | 0.83 | KDR (0.41) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL29968276 | 0.83 | KDR (0.41) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL29967962 | 0.80 | ABL1 (0.42) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL28871272 | 0.80 | NR1H4 (0.48) | MAPK8FLT3KITABL1BCR | |
| SCHEMBL28871288 | 0.80 | NR1H4 (0.46) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL29968066 | 0.79 | MAPK1 (0.41) | MAPK8KDRFLT3KITGSK3B | |
| SCHEMBL28871289 | 0.79 | MAPK1 (0.41) | MAPK8KDRFLT3KITGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |