SCHEMBL28874149

SCHEMBL28874149

O=C(c1ccccc1)N1CCC(C(=O)O)(C(=O)O)CC1

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.61
SIGMAR1 Q99720 1/20 0.58
CHRM2 P08172 1/20 0.56
CHRM3 P20309 1/20 0.56
CRBN Q96SW2 1/20 0.56
ALDH1A1 P00352 3/20 0.55
TP53 P04637 1/20 0.55
ACHE P22303 1/20 0.54
USP2 O75604 1/20 0.54
BLM P54132 1/20 0.53
LMNA P02545 1/20 0.52
MAPK1 P28482 1/20 0.51
CYP2D6 P10635 1/20 0.51
MAOB P27338 1/20 0.51
TSHR P16473 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28236571 0.86 HPGD (0.50) HPGDSIGMAR1CHRM2CHRM3CRBN
SCHEMBL17151131 0.82 HPGD (0.58) HPGDSIGMAR1CHRM2CHRM3CRBN
SCHEMBL8503467 0.82 HPGD (0.58) HPGDSIGMAR1CHRM2CHRM3CRBN
SCHEMBL7129676 0.82 HPGD (0.79) HPGDSIGMAR1ALDH1A1ACHEUSP2
SCHEMBL252026 0.82 HPGD (0.79) HPGDSIGMAR1ALDH1A1ACHEUSP2
SCHEMBL28911185 0.82 HPGD (0.53) HPGDSIGMAR1CHRM2CHRM3CRBN
SCHEMBL31435878 0.81 HPGD (0.61) HPGDSIGMAR1CHRM2CHRM3CRBN
SCHEMBL9928309 0.81 HPGD (0.61) HPGDSIGMAR1CHRM2CHRM3CRBN
Hydrochloric Acid SCHEMBL1597472 0.80 HPGD (0.76) HPGDSIGMAR1ALDH1A1ACHEUSP2
SCHEMBL3977397 0.79 HPGD (0.58) HPGDSIGMAR1CHRM2CHRM3CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109824472-A novel method for synthesizing gem-difluoroalkane and α -fluorocarboxylic acid 南京工业大学 2019-05-31 CN disclosed