Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 12/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876161 | 0.90 | HDAC3 (0.53) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28691437 | 0.88 | SYK (0.57) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28876167 | 0.87 | FLT3 (0.66) | FLT3BTKAURKAAURKBEGFR | |
| SCHEMBL28876156 | 0.87 | SYK (0.78) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28707054 | 0.82 | FLT3 (0.51) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28691453 | 0.81 | SYK (0.54) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28876164 | 0.81 | FLT3 (0.85) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL29463619 | 0.80 | SYK (0.69) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28876155 | 0.80 | SYK (0.69) | FLT3BTKSYKAURKAAURKB | |
| SCHEMBL28711742 | 0.79 | FLT3 (0.60) | FLT3BTKSYKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230524-A | (5-fluoro-2-anilinopyrimidin-4-yl) amino-N-hydroxybenzamide derivative and preparation method and application thereof | 南通大学 | 2022-03-25 | — | — | CN | claimed |
| CN-114230524-A | (5-fluoro-2-anilinopyrimidin-4-yl) amino-N-hydroxybenzamide derivative and preparation method and application thereof | 南通大学 | 2022-03-25 | — | — | CN | disclosed |