Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359691 | 0.85 | HDAC1 (0.75) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL28877751 | 0.83 | HDAC6 (0.81) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL13288530 | 0.77 | HDAC1 (0.69) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL28877707 | 0.76 | HDAC6 (0.68) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL6385727 | 0.76 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL6387051 | 0.76 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL28957938 | 0.76 | HDAC6 (0.69) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL24359341 | 0.76 | HDAC1 (0.77) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL8823169 | 0.76 | MAPT (1.00) | MAPTADORA3ALDH1A1ROCK1MEN1 | |
| SCHEMBL24359677 | 0.75 | HDAC1 (0.78) | HDAC6HDAC1HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141123-B | Compound, preparation method thereof and application thereof in preparation of dual inhibitors of histone deacetylase and epoxide hydrolase | 沈阳药科大学 | 2024-05-17 | — | — | CN | disclosed |
| CN-115141123-A | Compound, preparation method thereof and application thereof in preparation of histone deacetylase and epoxide hydrolase dual inhibitor | 沈阳药科大学 | 2022-10-04 | — | — | CN | disclosed |