SCHEMBL28877854

SCHEMBL28877854

CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(S(C)(=O)=O)nc2)c(=O)n3Cc2c(F)cccc2F)cc1

nearest known ligand 0.84

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 20/20 0.84
KCNH2 Q12809 9/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29967045 1.00 GNRHR (0.84) GNRHRKCNH2
SCHEMBL779928 0.91 GNRHR (1.00) GNRHRKCNH2
SCHEMBL29492062 0.91 GNRHR (0.82) GNRHRKCNH2
SCHEMBL30816235 0.89 GNRHR (0.85) GNRHRKCNH2
SCHEMBL29165476 0.89 GNRHR (0.85) GNRHRKCNH2
SCHEMBL22936827 0.89 GNRHR (0.83) GNRHRKCNH2
SCHEMBL29696437 0.89 GNRHR (0.83) GNRHRKCNH2
SCHEMBL779780 0.88 GNRHR (0.86) GNRHRKCNH2
SCHEMBL30461588 0.88 GNRHR (0.89) GNRHRKCNH2
SCHEMBL28979541 0.88 GNRHR (0.89) GNRHRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260211-B Thiophene condensed ring derivative, pharmaceutical composition, preparation method and application thereof 长春金赛药业有限责任公司 2024-02-06 CN disclosed
CN-115260211-A Thiophene fused ring containing derivative, pharmaceutical composition, preparation method and application thereof 长春金赛药业有限责任公司 2022-11-01 CN disclosed