Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23410811 | 0.80 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| SCHEMBL23410755 | 0.79 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| Lithium Ion SCHEMBL23410756 | 0.76 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| SCHEMBL23410379 | 0.75 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| Acetic Acid SCHEMBL28878571 | 0.72 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11GRM5 | |
| SCHEMBL23410888 | 0.71 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| SCHEMBL27565043 | 0.68 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11RIPK3 | |
| Acetic Acid SCHEMBL28878619 | 0.67 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3493215 | 0.66 | KDM4E (0.50) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL23410240 | 0.66 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151256-A | Novel compounds for the treatment of diseases associated with DUX expression | FACIO知识产权有限公司 | 2022-10-04 | — | — | CN | disclosed |