Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2887955 | 1.00 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CCYP1A2 | |
| SCHEMBL2887949 | 1.00 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CCYP1A2 | |
| SCHEMBL2882721 | 0.93 | PDE4D (0.58) | PDE4BPDE4DPDE4APDE4CSRC | |
| SCHEMBL2882717 | 0.93 | PDE4D (0.58) | PDE4BPDE4DPDE4APDE4CSRC | |
| SCHEMBL2882719 | 0.93 | PDE4D (0.58) | PDE4BPDE4DPDE4APDE4CSRC | |
| SCHEMBL2887679 | 0.92 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CCYP1A2 | |
| SCHEMBL2887676 | 0.92 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CCYP1A2 | |
| SCHEMBL2887681 | 0.92 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CCYP1A2 | |
| SCHEMBL2887026 | 0.92 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4CHPGD | |
| SCHEMBL2887030 | 0.92 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | claimed |
| US-7776893-B2 | Use of PDE4 inhibitors for the treatment of diabetes mellitus | NYCOMED GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20060281745-A1 | Use of pde4 inhibitors for the treatment of diabetes mellitus | ALTANA PHARMA AG (DE) | 2006-12-14 | — | — | US | disclosed |
| US-20060189641-A1 | Novel 6-phenlyphenanthridines | NYCOMED GMBH (DE) | 2006-08-24 | — | — | US | disclosed |
| US-20060189645-A1 | Novel 6-phenylphenantridines | ALTANA PHARMA AG (DE) | 2006-08-24 | — | — | US | disclosed |
| EP-1658270-A1 | NOVEL 6-PHENYLPHENANTRIDINES | ALTANA Pharma AG (DE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1658271-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA Pharma AG (DE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2005012253-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012252-A1 | NOVEL 6-PHENYLPHENANTRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189645-A1 | Novel 6-phenylphenantridines | PDE4B, PDE4A, PDE4D | PDE4B 1/4885PDE4D 3/4885PDE4A 2/4885 |
| US-20060189641-A1 | Novel 6-phenlyphenanthridines | PDE4A, PDE4B, PDE4C | PDE4B 2/4885PDE4D 5/4885PDE4A 1/4885 |
| US-20060281745-A1 | Use of pde4 inhibitors for the treatment of diabetes mellitus | PDE4A, PDE4B, PDE12 | PDE4B 2/4885PDE4D 4/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.