Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24942616 | 0.93 | HPGD (0.50) | HPGDMGLLVNN1HRH3DDR1 | |
| SCHEMBL31038242 | 0.93 | HPGD (0.50) | HPGDMGLLVNN1HRH3DDR1 | |
| SCHEMBL29564966 | 0.86 | HPGD (0.51) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL23675278 | 0.86 | HPGD (0.51) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL23680795 | 0.85 | HPGD (0.51) | HPGDMGLLVNN1HRH3PRKAA2 | |
| SCHEMBL29141099 | 0.84 | HPGD (0.45) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL23675218 | 0.84 | HPGD (0.47) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL23675215 | 0.84 | HPGD (0.47) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL29565058 | 0.84 | HPGD (0.47) | HPGDMGLLVNN1ADRA1ADDR1 | |
| SCHEMBL23680713 | 0.83 | HPGD (0.53) | HPGDMGLLVNN1ADRA1ADDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335043-A | PGDH inhibitors and methods of making and using | 迈欧伏特治疗公司 | 2022-11-11 | — | — | CN | disclosed |