Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887504 | 0.92 | JAK3 (0.43) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28887539 | 0.92 | EGFR (0.45) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887550 | 0.89 | JAK3 (0.57) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887598 | 0.85 | HPGD (0.41) | JAK3JAK2 | |
| SCHEMBL28887510 | 0.81 | JAK3 (0.58) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887501 | 0.81 | JAK3 (0.56) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887535 | 0.80 | JAK3 (0.57) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887608 | 0.79 | JAK3 (0.59) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL29127343 | 0.79 | JAK3 (0.44) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL28887528 | 0.77 | STAT6 (0.44) | JAK2JAK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |