Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.45 |
| ▸ | TYK2 | P29597 | 10/20 | 0.43 |
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887561 | 0.92 | EGFR (0.41) | JAK3JAK1JAK2KMT2AMEN1 | |
| SCHEMBL28887532 | 0.92 | JAK3 (0.49) | JAK3TYK2JAK1JAK2TTK | |
| SCHEMBL28959093 | 0.91 | JAK3 (0.43) | JAK3JAK1JAK2TTKACKR3 | |
| SCHEMBL28959064 | 0.91 | JAK1 (0.44) | JAK3TYK2JAK1JAK2 | |
| SCHEMBL28887519 | 0.89 | JAK3 (0.46) | JAK3JAK1JAK2KMT2AMEN1 | |
| SCHEMBL28887608 | 0.88 | JAK3 (0.59) | JAK3TYK2JAK1JAK2TTK | |
| SCHEMBL28887548 | 0.87 | JAK3 (0.51) | JAK3TYK2JAK1JAK2TTK | |
| SCHEMBL28887556 | 0.85 | JAK1 (0.43) | JAK3TYK2JAK1JAK2TTK | |
| SCHEMBL28887549 | 0.82 | HTT (0.41) | JAK3TYK2JAK1JAK2 | |
| SCHEMBL28887527 | 0.82 | JAK3 (0.45) | JAK3TYK2JAK1JAK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |