Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.59 |
| ▸ | JAK1 | P23458 | 9/20 | 0.57 |
| ▸ | JAK2 | O60674 | 6/20 | 0.57 |
| ▸ | TYK2 | P29597 | 5/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887559 | 0.92 | JAK3 (0.58) | JAK3JAK1JAK2TYK2AURKA | |
| SCHEMBL28887562 | 0.91 | JAK3 (0.51) | JAK3JAK1JAK2TYK2AURKA | |
| SCHEMBL28887484 | 0.89 | EGFR (0.48) | JAK3JAK1JAK2TYK2AURKA | |
| SCHEMBL28887513 | 0.89 | JAK3 (0.56) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL28887527 | 0.88 | JAK3 (0.45) | JAK3JAK1JAK2TYK2AURKA | |
| SCHEMBL28887565 | 0.86 | JAK3 (0.51) | JAK3JAK1JAK2TYK2BTK | |
| SCHEMBL28887563 | 0.84 | JAK1 (0.44) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28887542 | 0.83 | JAK3 (0.53) | JAK3JAK1JAK2TYK2AURKA | |
| SCHEMBL28887514 | 0.83 | JAK3 (0.46) | JAK3JAK1JAK2TYK2TTK | |
| SCHEMBL28887608 | 0.82 | JAK3 (0.59) | JAK3JAK1JAK2TYK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |