SCHEMBL2888937

SCHEMBL2888937

CO[Si](CCc1cccc(CBr)c1)(OC)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 2/20 0.42
CYP4A11 Q02928 2/20 0.42
TAAR1 Q96RJ0 1/20 0.40
CHRM2 P08172 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
SIGMAR1 Q99720 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA3 P34903 1/20 0.36
GABRA2 P47869 1/20 0.36
GABRB2 P47870 1/20 0.36
AOC3 Q16853 1/20 0.36
TRPA1 O75762 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
MTNR1A P48039 2/20 0.35
MTNR1B P49286 2/20 0.35
HRH3 Q9Y5N1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL574710 0.91 TAAR1 (0.46) CYP4F2CYP4A11TAAR1CHRM2CHRM1
SCHEMBL2955473 0.90 CHRM2 (0.40) CYP4F2CYP4A11TAAR1CHRM2CHRM1
SCHEMBL2332545 0.84 TAAR1 (0.41) CYP4F2CYP4A11TAAR1CHRM2CHRM1
SCHEMBL927487 0.83 CYP4F2 (0.38) CYP4F2CYP4A11TAAR1TRPA1ALDH1A1
SCHEMBL2887582 0.82 TAAR1 (0.40) CYP4F2CYP4A11TAAR1CHRM2CHRM1
SCHEMBL926607 0.82 TSHR (0.40) CYP4F2CYP4A11TAAR1CHRM2CHRM1
SCHEMBL9658109 0.82 TAAR1 (0.47) TAAR1CHRM2CHRM1CHRM3AOC3
SCHEMBL13429722 0.82 TAAR1 (0.52) TAAR1ALDH1A1
SCHEMBL927039 0.81 TAAR1 (0.36) CYP4F2CYP4A11TAAR1SIGMAR1AOC3
SCHEMBL2953816 0.80 CYP4F2 (0.36) CYP4F2CYP4A11TRPA1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121349-B1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2010-11-17 EP claimed
EP-2207782-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM Momentive Performance Materials Inc. (US) 2010-07-21 EP claimed
US-7625965-B2 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-12-01 US claimed
EP-2121349-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM Momentive Performance Materials Inc. (US) 2009-11-25 EP claimed
WO-2009058373-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-05-07 WO claimed
US-20090111923-A1 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2009-04-30 US claimed
WO-2008097587-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC (US) 2008-08-14 WO claimed
US-20080194746-A1 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2008-08-14 US claimed
EP-2708546-B1 Halo-Functional Silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MAT INC (US) 2016-01-06 EP disclosed
EP-2708546-A1 Halo-Functional Silane, process for its preparation, rubber composition containing same and articles manufactured therefrom Momentive Performance Materials Inc. (US) 2014-03-19 EP disclosed
EP-2207782-B1 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2014-02-26 EP disclosed
CN-102432924-A Rubber composition, method of making the same, and articles made therefrom MOMENTIVE PERFORMANCE MAT INC 2012-05-02 CN disclosed
EP-2121349-B1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2010-11-17 EP disclosed
US-7816435-B2 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-10-19 US disclosed
EP-2121349-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM Momentive Performance Materials Inc. (US) 2009-11-25 EP disclosed
WO-2009058373-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-05-07 WO disclosed
US-20090111923-A1 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2009-04-30 US disclosed
WO-2008097587-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC (US) 2008-08-14 WO disclosed
US-20080194746-A1 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2008-08-14 US disclosed
US-20080051487-A1 Process for Producing Polysilsesquioxane Graft Polymer, Pressure-Sensitive Adhesive, and Pressure-Sensitive Adhesive Sheet LINTEC CORPORATION (JP) 2008-02-28 US disclosed