⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133037 | 1.00 | — | — | |
| SCHEMBL2010084 | 0.78 | — | — | |
| SCHEMBL6487194 | 0.75 | — | — | |
| SCHEMBL31344998 | 0.73 | — | — | |
| SCHEMBL830189 | 0.71 | — | — | |
| SCHEMBL972050 | 0.69 | — | — | |
| SCHEMBL263643 | 0.69 | — | — | |
| SCHEMBL9249993 | 0.67 | — | — | |
| SCHEMBL13692730 | 0.67 | — | — | |
| SCHEMBL10807871 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578757-B1 | FLUOROGENIC ENZYME SUBSTRATES AND METHODS OF PREPARATION | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2014-10-22 | — | — | EP | disclosed |
| US-7863428-B2 | Fluorogenic enzyme substrates and methods of preparation | TIBOTEC BVBA (BE) | 2011-01-04 | — | — | US | disclosed |
| US-7652008-B2 | 2,2,7,9-tetramethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol; 3-hydroxy-2,2,9-trimethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-7-carbonitrile; have the prolongation effect on refractory period | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-01-26 | — | — | US | disclosed |
| US-20070037234-A1 | fluorophores containing 2-(3H-4-oxo-6-n-pentyl-2-quinazolinyl)-4-n-pentylphenyl phosphate; hydrolases; improved cell permeability; photostability | TIBOTEC BVBA (BE) | 2007-02-15 | — | — | US | disclosed |
| EP-1578757-A2 | FLUOROGENIC ENZYME SUBSTRATES AND METHODS OF PREPARATION | Tibotec BVBA (BE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058787-A2 | FLUOROGENIC ENZYME SUBSTRATES AND METHODS OF PREPARATION | TIBOTEC BVBA (BE) | 2004-07-15 | — | — | WO | disclosed |
| US-5444084-A | Anticholesterol, antilipidemic agents | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0609448-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVE HAVING SQUALENE EPOXIDASE INHIBITORY EFFECT AND USE THEREOF | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-10 | — | — | EP | disclosed |