Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.73 |
| ▸ | PDE1A | P54750 | 9/20 | 0.73 |
| ▸ | PDE1B | Q01064 | 9/20 | 0.73 |
| ▸ | PDE1C | Q14123 | 9/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.61 |
| ▸ | PDE6A | P16499 | 2/20 | 0.61 |
| ▸ | PDE2A | O00408 | 1/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | PDE9A | O76083 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | PDE6G | P18545 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | PDE6B | P35913 | 1/20 | 0.61 |
| ▸ | PDE6C | P51160 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973746 | 0.90 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL7389060 | 0.90 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL5767555 | 0.89 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL29663760 | 0.89 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CPDE4B | |
| Hydrochloric Acid SCHEMBL18167456 | 0.88 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL974080 | 0.88 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL13384838 | 0.88 | PDE5A (0.82) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL974965 | 0.86 | PDE5A (0.83) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL973698 | 0.86 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL973597 | 0.86 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111297868-A | Use of a composition comprising a heterocyclic compound for the manufacture of a medicament for the treatment of phosphodiesterase mediated diseases | 黄泳华 | 2020-06-19 | — | — | CN | claimed |
| CN-111297868-A | Use of a composition comprising a heterocyclic compound for the manufacture of a medicament for the treatment of phosphodiesterase mediated diseases | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |