Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 19/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896118 | 1.00 | NAMPT (0.90) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL31181445 | 0.95 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL29635857 | 0.95 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL82368 | 0.95 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL82367 | 0.95 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL156944 | 0.95 | NAMPT (1.00) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL23924298 | 0.94 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| SCHEMBL3458354 | 0.94 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| SCHEMBL3458355 | 0.94 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 | |
| Daporinad SCHEMBL30634180 | 0.94 | NAMPT (0.98) | NAMPTCYP3A4CYP2C9HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111454327-A | NAMPT protein degradation targeting chimera and preparation method and application thereof | 中国人民解放军第二军医大学 | 2020-07-28 | — | — | CN | disclosed |