Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896659 | 0.83 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2GRM1KDM4E | |
| SCHEMBL28896404 | 0.74 | TSHR (0.33) | TSHRALDH1A1SMN1; SMN2GRM1CCR2 | |
| SCHEMBL28896497 | 0.73 | GRM1 (0.36) | ALDH1A1GRM1KDM4EHPGDHSD17B10 | |
| SCHEMBL1536739 | 0.72 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL23234046 | 0.72 | GRM1 (0.43) | TSHRALDH1A1GRM1KDM4EHPGD | |
| SCHEMBL2573280 | 0.72 | GRM1 (0.43) | TSHRALDH1A1SMN1; SMN2GRM1KDM4E | |
| Hydrochloric Acid SCHEMBL25312311 | 0.71 | TSHR (0.44) | TSHRALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL28896589 | 0.68 | SMN1; SMN2 (0.35) | TSHRALDH1A1SMN1; SMN2GRM1KDM4E | |
| SCHEMBL22534131 | 0.68 | GRM1 (0.44) | TSHRALDH1A1SMN1; SMN2GRM1KDM4E | |
| SCHEMBL29788454 | 0.68 | GRM1 (0.44) | TSHRALDH1A1SMN1; SMN2GRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |