Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 15/20 | 0.62 |
| ▸ | MAOB | P27338 | 6/20 | 0.53 |
| ▸ | MAOA | P21397 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896354 | 1.00 | KDM1A (0.62) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL28426625 | 0.85 | KDM1A (0.62) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL28426624 | 0.85 | KDM1A (0.62) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL28428824 | 0.84 | KDM1A (0.58) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL28428825 | 0.84 | KDM1A (0.58) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL20308865 | 0.79 | KDM1A (0.55) | KDM1AMAOBMAOAGAAL3MBTL1 | |
| SCHEMBL2756020 | 0.77 | KDM1A (1.00) | KDM1AMAOBMAOAALDH1A1 | |
| SCHEMBL239559 | 0.77 | KDM1A (1.00) | KDM1AMAOBMAOAALDH1A1 | |
| SCHEMBL239558 | 0.77 | KDM1A (1.00) | KDM1AMAOBMAOAALDH1A1 | |
| SCHEMBL14701059 | 0.76 | KDM1A (0.62) | KDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105283177-B | Cyclopropylamine derivatives useful as inhibitors of histone demethylase KDM1A | 欧洲肿瘤研究所有限责任公司 | 2020-07-24 | — | — | CN | claimed |
| CN-105283177-B | Cyclopropylamine derivatives useful as inhibitors of histone demethylase KDM1A | 欧洲肿瘤研究所有限责任公司 | 2020-07-24 | — | — | CN | disclosed |