Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896079 | 0.97 | GAA (0.36) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL28896318 | 0.95 | KDM4E (0.36) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL28896479 | 0.80 | TSHR (0.33) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL21859784 | 0.76 | — | — | |
| SCHEMBL28392238 | 0.71 | GAA (0.44) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL1255240 | 0.68 | SMN1; SMN2 (0.41) | KMT2AALDH1A1TP53POLBSMN1; SMN2 | |
| SCHEMBL28601266 | 0.68 | MAPT (0.43) | GAAKMT2AALDH1A1POLBNLRP3 | |
| SCHEMBL14678153 | 0.67 | GAA (0.45) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL1607153 | 0.66 | GAA (0.48) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL11694444 | 0.66 | KDM4E (0.39) | GAAMGAMSIMGAM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |